Publications
Lei Li, Yoshikazu Honda-Okubo, Jeremy Baldwin, Richard Bowen, Helle Bielefeldt-Ohmann, Nikolai Petrovsky. Covax-19/Spikogen® vaccine based on recombinant spike protein extracellular domain with Advax-CpG55.2 adjuvant provides single dose protection against SARS-CoV-2 infection in hamsters. Vaccine;S0264-410X(22)00469-8.
Payam Tabarsi, Nassim Anjidani, Ramin Shahpari, Masoud Mardani, Araz Sabzvari, Babak Yazdani, Khashayar Roshanzamir, Behnam Bayatani, Ali Taheri, Nikolai Petrovsky, Lei Li, Saghar Barati. Safety and immunogenicity of SpikoGen®, an advax-cpg55.2-adjuvanted sars-cov-2 spike protein vaccine: a phase 2 randomized placebo-controlled trial in both seropositive and seronegative populations.Clin Microbiol Infect; S1198-743X(22)00207-5
Kairat Tabynov, Meruert Babayeva, Tair Nurpeisov, Gleb Fomin, U Saltabayeva, S Renu, GJ Renukaradhya, N Petrovsky. Evaluation of a Novel Adjuvanted Vaccine for Ultrashort Regimen Therapy of Artemisia Pollen-Induced Allergic Bronchial Asthma in a Mouse Model. Front Immunol13:828690.
Lucie Jelínková, Yevel Flores-Garcia, Sarah Shapiro, Bryce T Roberts, Nikolai Petrovsky, Fidel Zavala, Bryce Chackerian. A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model. npj Vaccines 7:34.
Kairat Tabynov, Nurkeldi Turebekov, Meruert Babayeva, Gleb Fomin, Toktassyn Yerubayev, Tlektes Yespolov, Lei Li, Gourapura J Renukaradhya, Nikolai Petrovsky, Kaissar Tabynov. An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission. npjVaccines ;7(1):24
Arshpreet Kaur, Rohini Kanwar, Deepender Kaushik, Isaac G Sakala, Yoshikazu Honda-Okubo, Nikolai Petrovsky, Deepak B Salunke, Surinder K Mehta. Combined delivery of TLR2 and TLR7 agonists by Nanostructured lipid carriers induces potent vaccine adjuvant activity in mice. International Journal of Pharmaceutics,Volume 613, 121378
Sakshi Piplani, Puneet Singh, Nikolai Petrovsky, David A Winkler. Computational Repurposing of Drugs and Natural Products Against SARS-CoV-2 Main Protease (Mpro) as Potential COVID-19 Therapies. Front Mol Biosci. 2022; 9: 781039
Sunil Thomas, Ann Abraham, Jeremy Baldwin, Sakshi Piplani, Nikolai Petrovsky. Artificial Intelligence in Vaccine and Drug Design.Vaccine Design131-146Humana, New York
Ali, ES. Petrovsky, N.Calcium Signaling As a Therapeutic Target for Liver Steatosis. Trends in Endocrinology & Metabolism. 2019 Apr;30(4):270-281. doi: 10.1016/j.tem.2019.02.005. Epub 2019 Mar 5. PMID:30850262
Barclay TG, Day CM, Petrovsky N, Garg S. Review of polysaccharide particle-based functional drug delivery. Carbohydr Polym. 2019 Oct 1;221:94-112. doi: 10.1016/j.carbpol.2019.05.067. Epub 2019 May 26. PMID: 31227171
Sakala IG, Eichinger KM, Petrovsky N. Neonatal vaccine effectiveness and the role of adjuvants. Expert Rev Clin Immunol. 2019 Aug;15(8):869-878. doi: 10.1080/1744666X.2019.1642748. Epub 2019 Jul 25. PMID: 31293189
Stewart E, Triccas JA, Petrovsky N. Adjuvant Strategies for More Effective Tuberculosis Vaccine Immunit. Microorganisms. 2019 Aug 12;7(8). 255. doi: 10.3390/microorganisms7080255. PMID:31409028
Li L, Honda-Okubo Y, Petrovsky N. Flavivirus DNA Vaccine Design and Adjuvant Selection. Methods Mol Biol. 2021;2183:405-422. doi: 10.1007/978-1-0716-0795-4_21. PMID: 32959256
Eichinger KM, Kosanovich JL, Lipp M, Empey KM, Petrovsky N. Strategies for active and passive pediatric RSV immunization Ther Adv Vaccines Immunother. 2021 Feb 10;9:2515135520981516. doi: 10.1177/2515135520981516. eCollection 2021. PMID: 33623860
Kaushik D, Kaur A, Petrovsky N, Salunke DB. Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles. RSC Med Chem. 2021 May 14;12(7):1065-1120. doi: 10.1039/d1md00031d. eCollection 2021 Jul 21. PMID: 34355178
Papte. S, Petrovsky N. Biological effects of excipients, In Handbook of Pharmaceutical Excipients, Pharmaceutical Press.
Royal Pharmaceutical Society, 2019
Varun Khanna, Shoba Ranganathan and Nikolai Petrovsky Rational Structure-Based Drug Design. In: Ranganathan, S., Nakai, K., Schönbach C. and Gribskov, M. (eds.), Encyclopedia of Bioinformatics and Computational Biology, vol. 2, pp. 585–600. (2019) Oxford: Elsevier
Tomar J, Biel C, de Haan CAM, Rottier PJM, Petrovsky N, Frijlink HW, Huckriede A, Hinrichs WLJ, Peeters B. Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge. Eur J Pharm Biopharm. 2018 Oct 9. pii: S0939-6411(18)30806-3. doi: 10.1016/j.ejpb.2018.10.008. PMID 30312742
Tomar J, Patil HP, Bracho G, Tonnis WF, Frijlink HW, Petrovsky N, Vanbever R, Huckriede A, Hinrichs WLJ. Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge. J Control Release. 2018 Oct 28;288:199-211. doi: 10.1016/j.jconrel.2018.09.006. Epub 2018 Sep 12. PMID: 30218687
Chris Weir, Annika Oksa, Jennifer Millar, Miles Alexander, Nicola Kynoch, Zoe Walton-Weitz, Peter Mackenzie-Wood, Felicia Tam, Hope Richards, Richard Naylor, Katrina Cheng, Peter Bennett, N Petrovsky and Rachel Allavena. The Safety of an Adjuvanted Autologous Cancer Vaccine Platform in Canine Cancer Patients Vet. Sci. 2018, 5(4), 87; doi:10.3390/vetsci5040087
Yu L, Sun Q, Hui Y, Seth A, Petrovsky N, Zhao CX. Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release. J Colloid Interface Sci. 2018 Dec 19;539:497-503. doi: 10.1016/j.jcis.2018.12.075.
Adney DR, Lingshu Wang, Neeltje van Doremalen, Wing-Pui Kong, Megan R. Miller, Trenton Bushmaker, Dana Scott, Emmie de Wit, Kayvon Modjarad, Barney Graham, Petrovsky N, Richard A. Bowen, Vincent J. Munster. Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and Alpacas. Viruses. 2019 Mar 2;11(3). pii: E212. doi: 10.3390/v11030212. PMID: 30832356
Heddle, B, Smith A, Woodman R, Hissaria P, Petrovsky N. Randomized controlled trial demonstrating benefits of delta inulin adjuvanted immunotherapy in bee venom allergic patients. Journal of Allergy and Clinical Immunology. 2019 Aug;144(2):504-513.e16. doi: 10.1016/j.jaci.2019.03.035. Epub 2019 Jul 9. PMID: 31300280
Wanandy T, Honda-Okubo Y, Davies NW, Rose HE, Heddle RJ, Brown SGA, Woodman RJ, Petrovsky N, Wiese MD. Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapy. J Pharm Biomed Anal. 2019 Aug 5;172:1-8. doi: 10.1016/j.jpba.2019.04.017. Epub 2019 Apr 9. PMID: 31009889
Afinjuomo F, Barclay TG, Parikh A, Song Y, Chung R, Wang L, Liu L, Hayball JD, Petrovsky N, Garg S. Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes. Pharmaceutics. 2019 May 22;11(5). pii: E243. doi: 10.3390/pharmaceutics11050243. PMID:31121836
Ran R, Wang HF, Hou F, Liu Y, Hui Y, Petrovsky N, Zhang F, Zhao CX. A Microfluidic Tumor-on-a-Chip for Assessing Multifunctional Liposomes' Tumor Targeting and Anticancer Efficacy. Adv Healthc Mater. 2019 Apr;8(8):e1900015. doi: 10.1002/adhm.201900015. Epub 2019 Mar 14. PMID: 30868753
Khanna V, Li L, Fung J, Ranganathan S, Petrovsky N. Prediction of novel mouse TLR9 agonists using a random forest approach. BMC Mol Cell Biol. 2019 Dec 20;20(Suppl 2):56. doi: 10.1186/s12860-019-0241-0. PMID:31856726
Davtyan H, Hovakimyan A, Kiani Shabestari S, Antonyan T, Coburn MA, Zagorski K, Chailyan G, Petrushina I, Svystun O, Danhash E, Petrovsky N, Cribbs DH, Agadjanyan MG, Blurton-Jones M, Ghochikyan A. Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. Alzheimers Res Ther. 2019 Dec 17;11(1):107. doi: 10.1186/s13195-019-0556-2. PMID: 31847886
Wang L, Song Y, Parikh A, Joyce P, Chung R, Liu L, Afinjuomo F, Hayball JD, Petrovsky N, Barclay TG, Garg S. Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation. Pharmaceutics. 2019 Nov 6;11(11). pii: E581. doi: 10.3390/pharmaceutics11110581. PMID: 31698755
Hovakimyan A, Antonyan T, Shabestari SK, Svystun O, Chailyan G, Coburn MA, Carlen-Jones W, Petrushina I, Chadarevian JP, Zagorski K, Petrovsky N, Cribbs DH, Agadjanyan MG, Ghochikyan A, Davtyan H. A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice. Sci Rep. 2019 Oct 29;9(1):15455. doi: 10.1038/s41598-019-51809-2.PMID 31664089
Afinjuomo F, Barclay TG, Parikh A, Chung R, Song Y, Nagalingam G, Triccas J, Wang L, Liu L, Hayball JD, Petrovsky N, Garg S. Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery. Pharmaceutics. 2019 Oct 28;11(11). pii: E555. doi: 10.3390/pharmaceutics11110555. PMID 31661841
Rivera-Hernandez T, Rhyme MS, Cork AJ, Jones S, Segui-Perez C, Brunner L, Richter J, Petrovsky N, Lawrenz M, Goldblatt D, Collin N, Walker MJ. Vaccine-Induced Th1-Type Response Protects against Invasive Group A Streptococcus Infection in the Absence of Opsonizing Antibodies. mBio. 2020 Mar 10;11(2). pii: e00122-20. doi: 10.1128/mBio.00122-20. PMID:32156809
Afinjuomo F, Fouladian P, Barclay TG, Song Y, Petrovsky N, Garg S. Influence of Oxidation Degree on the Physicochemical Properties of Oxidized Inulin. Polymers (Basel). 2020 May 1;12(5). pii: E1025. doi: 10.3390/polym12051025.PMID:32369991
Kaushik D, Dhingra S, Patil MT, Piplani S, Khanna V, Honda-Okubo Y, Li L, Fung J, Sakala IG, Salunke DB, Petrovsky N. BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant. Hum Vaccin Immunother. 2020 Apr 16:1-8. doi: 10.1080/21645515.2019.1710409. PMID:32298200
Stronsky SM, Cooper CL, Steffens J, Van Tongeren S, Bavari S, Martins KA, Petrovsky N. Adjuvant selection impacts the correlates of vaccine protection against Ebola infection. Vaccine. 2020 Jun 15;38(29):4601-4608. doi: 10.1016/j.vaccine.2020.05.009. Epub 2020 May 6. PMID: 32418798
Eichinger KM, Kosanovich JL, Gidwani SV, Zomback A, Lipp MA, Perkins TN, Oury TD, Petrovsky N, Marshall CP, Yondola MA, Empey KM . Prefusion RSV F Immunization Elicits Th2-Mediated Lung Pathology in Mice When Formulated With a Th2 (but Not a Th1/Th2-Balanced) Adjuvant Despite Complete Viral Protection. Front Immunol. 2020 Jul 29;11:1673. doi: 10.3389/fimmu.2020.01673. eCollection 2020. PMID: 32849580
Geberhiwot T, Baig S, Obringer C, Girard D, Dawson C, Manolopoulos K, Messaddeq N, Bel Lassen P, Clement K, Tomlinson JW, Steeds RP, Dollfus H, Petrovsky N, Marion V . Relative Adipose Tissue Failure in Alström Syndrome Drives Obesity-Induced Insulin Resistance. Diabetes. 2020 Sep 29:db200647. doi: 10.2337/db20-0647. Online ahead of print. PMID: 32994277
Eichinger KM, Kosanovich JL, Lipp MA, Perkins TN, Petrovsky N, Marshall C, Yondola MA, Empey KM. Maternal immunization with adjuvanted RSV prefusion F protein effectively protects offspring from RSV challenge and alters innate and T cell immunity. Vaccine. 2020 Nov 25;38(50):7885-7891. doi: 10.1016/j.vaccine.2020.10.065. Epub 2020 Oct 29. PMID: 33129608
Ferrell KC, Stewart EL, Counoupas C, Ashhurst TM, Britton WJ, Petrovsky N, Triccas JA. Intrapulmonary vaccination with delta-inulin adjuvant stimulates non-polarised chemotactic signalling and diverse cellular interaction. Mucosal Immunol. 2021 Feb 4:1-12. doi: 10.1038/s41385-021-00379-6. Online ahead of print. PMID: 33542494
Ryan NM, Hess JA, de Villena FP, Leiby BE, Shimada A, Yu L, Yarmahmoodi A, Petrovsky N, Zhan B, Bottazzi ME, Makepeace BL, Lustigman S, Abraham D. Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. NPJ Vaccines. 2021 Jan 26;6(1):17. doi: 10.1038/s41541-020-00276-2. PMID: 33500417.
Jelínková L, Jhun H, Eaton A, Petrovsky N, Zavala F, Chackerian B. An epitope-based malaria vaccine targeting the junctional region of circumsporozoite protein. NPJ Vaccines. 2021 Jan 21;6(1):13. doi: 10.1038/s41541-020-00274-4. PMID: 33479242.
Blake S, Bremer PT, Zhou B, Petrovsky N, Smith LC, Hwang CS, Janda KD. Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability. Mol Pharm. 2021 Jan 4;18(1):228-235. doi: 10.1021/acs.molpharmaceut.0c00837. Epub 2020 Dec 10. PMID: 33301675.
Kaur A, Kaushik D, Piplani S, Mehta SK, Petrovsky N, Salunke DB. TLR2 Agonistic Small Molecules: Detailed Structure-Activity Relationship, Applications, and Future Prospects. J Med Chem. 2021 Jan 14;64(1):233-278. doi: 10.1021/acs.jmedchem.0c01627. Epub 2020 Dec 21. PMID: 33346636.
Counoupas C, Ferrell KC, Ashhurst A, Bhattacharyya ND, Nagalingam G, Stewart EL, Feng CG, Petrovsky N, Britton WJ, Triccas JA. Mucosal delivery of a multistage subunit vaccine promotes development of lung-resident memory T cells and affords interleukin-17-dependent protection against pulmonary tuberculosis. NPJ Vaccines. 2020 Nov 12;5(1):105. doi: 10.1038/s41541-020-00255-7. PMID: 33298977
Quan DH, Counoupas C, Nagalingam G, Pinto R, Petrovsky N, Britton WJ, Triccas JA. Advax adjuvant formulations promote protective immunity against aerosol Mycobacterium tuberculosis in the absence of deleterious inflammation and reactogenicity. Vaccine. 2021 Apr 1;39(14):1990-1996. doi: 10.1016/j.vaccine.2021.02.041. Epub 2021 Mar 11. PMID: 3371465
Luczo JM, Bousse T, Johnson SK, Jones CA, Pearce N, Neiswanger CA, Wang MX, Miller EA, Petrovsky N, Wentworth DE, Bronshtein V, Papania M, Tompkins SM. Intranasal powder live attenuated influenza vaccine is thermostable, immunogenic, and protective against homologous challenge in ferrets. NPJ Vaccines. 2021 Apr 21;6(1):59. doi: 10.1038/s41541-021-00320-9. PMID: 33883559
Ali ES, Girard D, Petrovsky N. Impaired Ca 2+ signaling due to steatosis mediates hepatic insulin resistance in Alstrom Syndrome mice that is reversed by GLP-1 analog treatment Am J Physiol Cell Physiol. 2021 Jun 9. doi: 10.1152/ajpcell.00020.2021. Online ahead of print. PMID: 34106786
Sundaram AK, Ewing D, Liang Z, Jani V, Cheng Y, Sun P, Raviprakash K, Wu SJ, Petrovsky N, Defang G, Williams M, Porter KR. Immunogenicity of Adjuvanted Psoralen-Inactivated SARS-CoV-2 Vaccines and SARS-CoV-2 Spike Protein DNA Vaccines in BALB/c Mice. Pathogens. 2021 May 19;10(5):626. doi: 10.3390/pathogens10050626. PMID: 34069575
Kaushik D, Granato JT, Macedo GC, Dib PRB, Piplani S, Fung J, da Silva AD, Coimbra ES, Petrovsky N, Salunke DB. Toll-like receptor-7/8 agonist kill Leishmania amazonensis by acting as pro-oxidant and pro-inflammatory agent. J Pharm Pharmacol. 2021 May 3:rgab063. doi: 10.1093/jpp/rgab063. Online ahead of print. PMID: 33940589
Honda-Okubo Y, Baldwin J, Petrovsky, N. Advax-CpG adjuvant provides antigen dose-sparing and enhanced immunogenicity for inactivated poliomyelitis virus vaccines. Pathogens 2021 Apr 21;10(5):500. doi: 10.3390/pathogens10050500. PMID: 33919442
Sakala IG, Honda-Okubo Y, Li L, Baldwin J, Petrovsky N. A M2 protein-based universal influenza vaccine containing Advax-SM adjuvant provides newborn protection via maternal or neonatal immunization. Vaccine. 2021 Aug 23;39(36):5162-5172. doi: 10.1016/j.vaccine.2021.07.037. Epub 2021 Aug 3. PubMed PMID: 34362601.
Piplani S, Singh PK, Winkler DA, Petrovsky N. In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin. Sci Rep. 2021 Jun 24;11(1):13063. doi: 10.1038/s41598-021-92388-5. PMID: 34168168
Wüthrich M, Dobson HE, Ledesma Taira C, Okaa UJ, Dos Santos Dias L, Isidoro-Ayza M, Petrovsky N, Klein BS. Combination Adjuvants Enhance Recombinant Protein Vaccine Protection against Fungal Infection. mBio. 2021 Aug 31;12(4):e0201821. doi: 10.1128/mBio.02018-21. Epub 2021 Aug 17. PubMed PMID: 34399628; PubMed Central PMCID: PMC8406321.
Görander S, Honda-Okubo Y, Bäckström M, Baldwin J, Bergström T, Petrovsky N, Liljeqvist JÅ. A truncated glycoprotein G vaccine formulated with Advax-CpG adjuvant provides protection of mice against genital herpes simplex virus 2 infection. Vaccine. 2021 Aug 26;. doi: 10.1016/j.vaccine.2021.08.050. [Epub ahead of print] PubMed PMID: 34456075.
Li L, Honda-Okubo Y, Huang Y, Jang H, Carlock MA, Baldwin J, Piplani S, Bebin-Blackwell AG, Forgacs D, Sakamoto K, Stella A, Turville S, Chataway T, Colella A, Triccas J, Ross TM, Petrovsky N. Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection. Vaccine. 2021 Aug 3;. doi: 10.1016/j.vaccine.2021.07.087. [Epub ahead of print] PubMed PMID: 34420786; PubMed Central PMCID: PMC8328570.
Jeremy Baldwin, Sakshi Piplani, Isaac G Sakala, Yoshikazu Honda-Okubo, Lei Li, Nikolai Petrovsky. Rapid development of analytical methods for evaluating pandemic vaccines: a COVID-19 perspective. Bioanalysis 2021 Dec;13(24):1805-1826.doi: 10.4155/bio-2021-0096.Epub 2021 Oct 14. PMID:34645288.
Sakshi Piplani,Puneet Kumar Singh,David A. Winkler, Nikolai Petrovsky. Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapies.2021; Mol Biomed. 2(1):28. doi: 10.1186/s43556-021-00050-3.Epub 2021 Sep 20. PMID:34766004
Computational repurposing of drugs and natural products against SARS-CoV-2 main protease (Mpro) as putative COVID-19 therapies. Frontiers in Molecular Biosciences, accepted.
Barclay T, Rajapaksha H, Thilagam A, Qian G, Ginic-Markovic M, Cooper P, Gerson A, Petrovsky N. Physical characterization and in silico modeling of inulin polymer conformation during vaccine adjuvant particle formation. Carbohydrate Polymers, 2016 Jun 5;143:108-15. doi: 10.1016/j.carbpol.2016.01.062. Epub 2016 Jan 29. PMID: 27083349
McPherson C, Chubet R, Holtz K, Honda-Okubo Y, Barnard D, Cox M, Petrovsky N. Development of a SARS Coronavirus Vaccine from Recombinant Spike Protein Plus Delta Inulin Adjuvant. Methods Mol Biol. 2016;1403:269-84. doi: 10.1007/978-1-4939-3387-7_14. PMID: 27076136
Gordon DL, Sajkov D, Honda-Okubo Y, Wilks SH, Aban M, Barr IG, Petrovsky N. Human Phase 1 trial of low-dose inactivated seasonal influenza vaccine formulated with Advax™ delta inulin adjuvant. Vaccine. 2016 Jul 19;34(33):3780-6. doi: 10.1016/j.vaccine.2016.05.071. Epub 2016 Jun 21.PMID: 27342914
Hess JA, Zhan B, Torigian AR, Patton JB, Petrovsky N, Zhan T, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. PLoS Negl Trop Dis. 2016 Jul 7;10(7):e0004797. doi: 10.1371/journal.pntd.0004797. eCollection 2016 Jul. PMID: 27387453
Davtyan H, Zagorski K, Rajapaksha H, Hovakimyan A, Davtyan A, Petrushina I, Kazarian K, Cribbs DH, Petrovsky N, Agadjanyan MG, Ghochikyan A. Alzheimer's disease Advax(CpG)- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules. Sci Rep. 2016 Jul 1;6:28912. doi: 10.1038/srep28912.PMID:27363809
Wong TM, Petrovsky N, Bissel SJ, Wiley CA, Ross TM. Delta inulin-derived adjuvants that elicit Th1 phenotype following vaccination reduces respiratory syncytial virus lung titers without a reduction in lung immunopathology. Hum Vaccin Immunother. 2016 May 24:1-10. PMID:27215855
Hayashi M, Aoshi T, Haseda Y, Kobiyama K, Wijaya E, Nakatsu N, Igarashi Y, Standley DM, Yamada H, Honda-Okubo Y, Hara H, Saito T, Takai T, Coban C, Petrovsky N, Ishii KJ. Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines. EBioMedicine. 2017 Feb;15:127-136. doi: 10.1016/j.ebiom.2016.11.015.
Rajapaksha H, Bhatia H, Wegener K, Petrovsky N, Bruning JB. X-ray crystal structure of rivoglitazone bound to PPARγ and PPAR subtype selectivity of TZDs. Biochim Biophys Acta. 2017 May 9. pii: S0304-4165(17)30160-5. doi: 10.1016/j.bbagen.2017.05.008. PMID 28499821
Honda-Okubo Y, Rajapaksha H, Sajkov D, Gordon D, Cox MM, Petrovsky N. Panblok-H1+advax H1N1/2009pdm vaccine: Insights into rapid development of an delta inulin adjuvanted recombinant pandemic influenza vaccine. Hum Vaccin Immunother. 2017 Feb 14:1-11. doi: 10.1080/21645515.2017.1279765. PMID:28301280
Counoupas C, Pinto R, Nagalingam G, Britton WJ, Petrovsky N, Triccas JA. Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection. Sci Rep. 2017 Aug 17;7(1):8582. doi: 10.1038/s41598-017-09119-y. PMID:28819247
Menon V, Ayala VI, Rangaswamy SP, Kalisz I, Whitney S, Galmin L, Ashraf A, LaBranche C, Montefiori D, Petrovsky N, Kalyanaraman VS, Pal R.J. DNA prime/protein boost vaccination elicits robust humoral response in rhesus macaques using oligomeric simian immunodeficiency virus envelope and Advax delta inulin adjuvant. J Gen Virol. 2017 Aug;98(8):2143-2155. doi: 10.1099/jgv.0.000863. Epub 2017 Jul 31. PMID:28758637
Wang L, Barclay T, Song Y, Joyce P, Sakala IG, Petrovsky N*, Garg S*. Investigation of the biodistribution, breakdown and excretion of delta inulin adjuvant. Vaccine. 2017 Aug 3;35(34):4382-4388. doi: 10.1016/j.vaccine.2017.06.045. Epub 2017 Jul 1. PMID:28676380.
O'Meara CP, Armitage CW, Andrew DW, Kollipara A, Lycke NY, Potter AA, Gerdts V, Petrovsky N, Beagley KW. Multistage vaccines containing outer membrane, type III secretion system and inclusion membrane proteins protects against a Chlamydia genital tract infection and pathology.Vaccine. 2017 Jul 5;35(31):3883-3888. doi: 10.1016/j.vaccine.2017.05.063. Epub 2017 Jun 8. PMID: 28602608
Mailybayeva A, Yespembetov B, Ryskeldinova S, Zinina N, Sansyzbay A, Renukaradhya GJ, Petrovsky N, Tabynov K. Improved influenza viral vector based Brucella abortus vaccine induces robust B and T-cell responses and protection against Brucella melitensis infection in pregnant sheep and goats. PLoS One. 2017 Oct 12;12(10):e0186484. doi: 10.1371/journal.pone.0186484. eCollection 2017.PMID: 29023541
De Paula Oliveira Santos B, Trentini MM, Machado RB, Rúbia Nunes Celes M, Kipnis A, Petrovsky N, Junqueira-Kipnis AP. Advax4 delta inulin combination adjuvant together with ECMX, a fusion construct of three protective mTB antigens, induces a potent Th1 immune response and protects mice against Mycobacterium tuberculosis infection.Hum Vaccin Immunother. 2017 Sep 22:0. doi: 10.1080/21645515.2017.1368598. PMID:28937879
Adamson PJ, Al Kindi MA, Wang JJ, Colella AD, Chataway TK, Petrovsky N, Gordon TP, Gordon DL. Proteomic analysis of influenza haemagglutinin-specific antibodies following vaccination reveals convergent immunoglobulin variable region signatures. Vaccine. 2017 Oct 9;35(42):5576-5580. doi: 10.1016/j.vaccine.2017.08.053. Epub 2017 Sep 6. PMID 28888340
Tomar J, Biel C, de Haan CAM, Rottier PJM, Petrovsky N, Frijlink HW, Huckriede A, Hinrichs WLJ, Peeters B. Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge. Eur J Pharm Biopharm. 2018 Oct 9. pii: S0939-6411(18)30806-3. doi: 10.1016/j.ejpb.2018.10.008. PMID 30312742
Tomar J, Patil HP, Bracho G, Tonnis WF, Frijlink HW, Petrovsky N, Vanbever R, Huckriede A, Hinrichs WLJ. Advax augments B and T cell responses upon influenza vaccination via the respiratory tract and enables complete protection of mice against lethal influenza virus challenge. J Control Release. 2018 Oct 28;288:199-211. doi: 10.1016/j.jconrel.2018.09.006. Epub 2018 Sep 12. PMID: 30218687
Cooper P, Barclay T, Ginic-Markovic M, Petrovsky N. Gamma ray sterilization of delta inulin adjuvant particles (Advax) makes minor, partly reversible structural changes without affecting adjuvant activity. Vaccine 2013. Jan 23;32(5):552-7. doi: 10.1016/j.vaccine.2013.11.105. Epub 2013 Dec 14. PMID: 24342245
Cooper P, Barclay T, Ginic-Markovic M, Gerson A, Petrovsky N. Inulin isoforms differ by repeated additions of one crystal unit cell. Carbohydrate Polymers 2014; Mar 15;103:392-7. doi: 10.1016/j.carbpol.2013.12.066. Epub 2013 Dec 31. PMID: 24528745
Feinen B, Petrovsky N, Verma A, Merkel TJ. Advax-adjuvanted Recombinant Protective Antigen Provides Protection Against Inhalational Anthrax That is Further Enhanced by Addition of Murabutide Adjuvant. Clin Vaccine Immunol. 2014 Apr;21(4):580-6. doi: 10.1128/CVI.00019-14. Epub 2014 Feb 19. PMID: 24554695
Capitani M, Saade F, Havas KM, Angeletti M, Concetti F, Agas D, Sabbieti MG, Concetti A, Venanzi FM, Petrovsky N. Plasmids Encoding Protein Aggregation Domains act as Molecular Adjuvants for DNA Vaccines. Curr Gene Ther. 2014;14(3):161-9. PMID: 24828254
Rajapaksha H, Petrovsky N. In Silico Structural Homology Modelling and Docking for Assessment of Pandemic Potential of a Novel H7N9 Influenza Virus and Its Ability to Be Neutralized by Existing Anti-Hemagglutinin Antibodies. PLoS One. 2014 Jul 21;9(7):e102618. doi: 10.1371/journal.pone.0102618. PMID: 25047593
Honda-Okubo Y, Kolpe A, Li L, Petrovsky N. A single immunization with inactivated H1N1 influenza vaccine formulated with delta inulin adjuvant (Advax™) overcomes pregnancy-associated immune suppression and enhances passive neonatal protection. Vaccine. 2014 Aug 6;32(36):4651-9. doi: 10.1016/j.vaccine.2014.06.057. Epub 2014 Jun 21. PMID: 24958701
Gordon D, Kelley P, Heinzel S, Cooper P, Petrovsky N. Immunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: A randomized controlled Phase 1 study. Vaccine. 2014 Nov 12;32(48):6469-77. doi: 10.1016/j.vaccine.2014.09.034. PMID:25267153
Cooper P, Rajapaksha H, Barclay T, Ginic-Markovic M, Gerson A, Petrovsky N. Inulin crystal initiation via a glucose-fructose cross-link of adjacent polymer chains: atomic force microscopy and static molecular modelling. Carbohydrate Polymers. 2015 Mar 6;117:964-72. doi: 10.1016/j.carbpol.2014.10.022. Epub 2014 Oct 23, PMID: 25498723
Murugappan S, Frijlink HW, Petrovsky N, Hinrichs WL. Enhanced Pulmonary Immunization with Aerosolized Inactivated Influenza Vaccine Containing Delta Inulin Adjuvant. European Journal of Pharmaceutical Sciences, 2014 Oct 20;66C:118-122. doi: 10.1016/j.ejps.2014.10.008. [Epub ahead of print] PMID: 25459531
Bielefeldt-Ohmann H, Prow NA, Wang W, Tan CS, Coyle M, Douma A, Hobson-Peters J, Kidd L, Hall RA, Petrovsky N. Safety and immunogenicity of a delta inulin adjuvanted inactivated Japanese encephalitis virus vaccine in pregnant mares and foals. Veterinary Research, 2014 Dec 17;45(1):130. PMID: 25516480
Honda-Okubo Y, Barnard D, Ong CH, Peng BH, Tseng CT, Petrovsky N. SARS-CoV vaccines formulated with delta inulin adjuvants provide enhanced virus protection while ameliorating lung eosinophilic immunopathology. J Virol. 2014 Dec 17. pii: JVI.02980-14. PMID: 25520500
Rodriguez-Del Rio E, Marradi M, Calderon-Gonzalez R, Frande-Cabanes E, Penadés S, Petrovsky N, Alvarez-Dominguez C. A gold glyco-nanoparticle carrying a Listeriolysin O peptide and formulated with Advax™ delta inulin adjuvant induces robust T-cell protection against listeria infection. Vaccine. 2015 Mar 17;33(12):1465-73. doi: 10.1016/j.vaccine.2015.01.062. Epub 2015 Feb 7. PMID: 25659269
Calderon-Gonzalez R, Tobes R, Pareja E, Frande-Cabanes E, Petrovsky N, Alvarez-Dominguez C. Identification and characterisation of T-cell epitopes for incorporation into dendritic cell-delivered listeria vaccines. J Immunol Methods. 2015 May 29. pii: S0022-1759(15)30002-8. doi: 10.1016/j.jim.2015.05.009. PMID:26031451
Honda Y, Ong CH, Petrovsky N. Advax Delta Inulin Adjuvant Overcomes Immune Immaturity In Neonatal Mice Thereby Allowing Single-Dose Influenza Vaccine Protection. Vaccine. 2015 Jul 29. pii: S0264-410X(15)01012-9. doi: 10.1016/j.vaccine.2015.07.051. [Epub ahead of print] PMID: 26232344
Li L, Honda Y, Li C, Petrovsky N. Delta inulin adjuvant enhances plasmablast generation, expression of activation-induced cytidine deaminase and B-cell affinity maturation in human subjects receiving seasonal influenza vaccine. PLOSOne, 2015 Jul 15;10(7):e0132003. doi: 10.1371/journal.pone.0132003. eCollection 2015.PMID 26177480
An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. Lobigs M, Pavy M, Hall RA, Lobigs P, Cooper P, Komiya T, Toriniwa H, Petrovsky N. J Gen Virol. 2010 Jun;91(Pt 6):1407-17. Epub 2010 Feb 3.PMID:20130134 Free full text Related citations
Immunomodulation with microbial vaccines to prevent type 1 diabetes mellitus. Petrovsky N. Nat Rev Endocrinol. 2010 Mar;6(3):131-8. Review. PMID 20173774 Related citations
Lessons learned from the H1N1 2009 pandemic.Petrovsky N. Hum Vaccin. 2010 Oct;6(10):780-3. Epub 2010 Oct 1. PMID 20935468 Related citations
Delta inulin: a novel, immunologically active, stable packing structure comprising B-D-[2 -> 1] poly(fructo-furanosyl)-D-glucose polymers. Cooper PD, Petrovsky N. Glycobiology. 2011 May;21(5):595-606. Epub 2010 Dec 7. PMID: 21147758 Related citations
Challenges in improving influenza vaccine protection in the elderly. Petrovsky N, Ross TM. Expert Rev Vaccines. 2011 Jan;10(1):7-11. PMID: 21162614 Free ArticleInduction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations. Cristillo AD, Ferrari MG, Hudacik L, Lewis B, Galmin L, Bowen B, Thompson D, Petrovsky N, Markham P, Pal R. J Gen Virol. 2011 Jan;92(Pt 1):128-40. PMID: 21169215 Related citations
The vaccine renaissance. Petrovsky N. Hum Vaccin. 2011 Feb 1;7(2). PMID: 21321480 Related citations
Serological responses following influenza A H1N1 2009 infection in adults. Tan S, Gordon DL, Honda-Okubo Y, Petrovsky N, Phillips P, Huddleston S, Sadlon TA. J Infect. 2011 May;62(5):388-93. Epub 2011 Mar 21. PMID: 21420426 Related citations
Carbohydrate-based immune adjuvants. Petrovsky N, Cooper PD. Expert Rev Vaccines. 2011 Apr;10(4):523-37. PMID: 21506649 Related citations
Pediatric influenza immunization. Petrovsky N, Sajkov D. Expert Rev Vaccines. 2011 May;10(5):567-70. No abstract available. PMID: 21604977. Free Article Related citations
Focus on influenza vaccines. Petrovsky N. Hum Vaccin. 2009 Oct;5(10):658-9. Epub 2009 Oct 21. No abstract available. PMID: 19667763. Free Article Related citations
AFCo1, a meningococcal B-derived cochleate adjuvant, strongly enhances antibody and T-cell immunity against Plasmodium falciparum merozoite surface protein 4 and 5. Bracho G, Zayas C, Wang L, Coppel R, Pérez O, Petrovsky N. Malar J. 2009 Feb 27;8:35. PMID: 19250541 Free PMC Article
Freeing vaccine adjuvants from dangerous immunological dogma. Petrovsky N. Expert Rev Vaccines. 2008 Feb;7(1):7-10. Review. No abstract available. PMID: 18251687 Free Article Related citations
Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Petrovsky N. Vaccine. 2006 Apr 12;24 Suppl 2:S2-26-9. Review. PMID: 16823913 Free full text Related citations
Information technologies for vaccine research. Brusic V, August JT, Petrovsky N. Expert Rev Vaccines. 2005 Jun;4(3):407-17. Review. PMID: 16026252 Related citations
Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses.Silva DG, Cooper PD, Petrovsky N. Immunol Cell Biol. 2004 Dec;82(6):611-6. Review. PMID: 15550119 Free Article Related citations
The future for computational modelling and prediction systems in clinical immunology. Petrovsky N, Silva D, Brusic V. Novartis Found Symp. 2003;254:23-32; discussion 33-42, 98-101, 250-2. Review. PMID: 14712930 Related citations
Computational methods for prediction of T-cell epitopes--a framework for modelling, testing, and applications. Brusic V, Bajic VB, Petrovsky N. Methods. 2004 Dec;34(4):436-43. Review. PMID:15542369 Related citations
Development of a nasal vaccine for chronic hepatitis B infection that uses the ability of hepatitis B core antigen to stimulate a strong Th1 response against hepatitis B surface antigen. Aguilar JC, Lobaina Y, Muzio V, García D, Pentón E, Iglesias E, Pichardo D, Urquiza D, Rodríguez D, Silva D, Petrovsky N, Guillén G. Immunol Cell Biol. 2004 Oct;82(5):539-46. PMID: 15479440Free Article Related citations
Virtual models of the HLA class I antigen processing pathway.Petrovsky N, Brusic V.Methods. 2004 Dec;34(4):429-35. Review. PMID: 15542368 Related citations
Vaccine adjuvants: current state and future trends. Petrovsky N, Aguilar JC. Immunol Cell Biol. 2004 Oct;82(5):488-96. Review. PMID: 15479434 Free Article Related citations
Prevention of autoimmune diabetes through immunostimulation with Q fever complement-fixing antigen.Silva DG, Charlton B, Cowden W, Petrovsky N. Ann N Y Acad Sci. 2003 Nov;1005:423-30. PMID:14679105 Related citations
Computational tools for the study of allergens. Brusic V, Petrovsky N, Gendel SM, Millot M, Gigonzac O, Stelman SJ. Allergy. 2003 Nov;58(11):1083-92. PMID: 14616117 Related citations
Vaccine therapies for the prevention of type 1 diabetes mellitus. Petrovsky N, Silva D, Schatz DA. Paediatr Drugs. 2003;5(9):575-82. PMID: 12956615 Related citations
Vaxine has developed a range of vaccine adjuvant technologies that are protected by international patents. It also has rights to international patents protecting its universal influenza vaccine technology. Additional patents are being sought to cover Vaxine novel immuno-modulators and cancer therapies.